The player is not limited to one support action per life and can earn them continuously. If a player earns a certain number of points before dying, called a score chain, he or she earns a choice of an offensive support action such as a mortar strike or missile attack or a defensive support action such as intel or ammo. For example, at the start of the game the sniper class does not have a proper sniper scope available, and the player must reach level 3 to unlock a combat scope. The player earns experience during gameplay to level up and unlock additional weapons and weapon accessories. Multiplayer is class based, with three classes available – Rifleman, Special Ops, and Sniper. Medal of Honor's multiplayer was developed by EA DICE. Army Ranger Specialist Dante Adams of the 75th Ranger Regiment, and AH-64 Apache gunner Brad 'Hawk' Hawkins. For the remainder, the player alternates between the roles of a Delta Force sniper codenamed Deuce, as well as U.S. For half of the game, players assume the role of a Navy SEAL DEVGRU operator codenamed Rabbit. The campaign takes place in Afghanistan, in 2002. The game's single-player campaign was developed by newly opened EA Los Angeles studio Danger Close Games. Players can request ammo from teammates in the single-player campaign, though this is limited. The modification of Unreal Engine 3.0 allows players to slide to cover and other combat moves.

Typical in-game objectives include raiding enemy hideouts, hostage rescues and undercover operations. Gameplay focuses on portraying operations in Afghanistan. A sequel, Medal of Honor: Warfighter, developed by Danger Close Games, was released on Octoin North America, in Australia on Octoand in Europe on October 26, 2012. The game received positive reviews from critics and was a commercial success. Medal of Honor's single-player campaign uses a modified Unreal Engine 3 while multiplayer uses the Frostbite Engine. The game is loosely based on parts of Operation Anaconda specifically, the events surrounding the Battle of Roberts Ridge. While the previous titles were set during World War II, Medal of Honor takes place during the War in Afghanistan. The game was released for Microsoft Windows, PlayStation 3 and Xbox 360 on October 12, 2010. It is the thirteenth installment in the Medal of Honor series and a reboot of the series. Medal of Honor is a first-person shooter video game developed by Danger Close Games and EA DICE and published by Electronic Arts.

Medal of honor 2010 game modes